The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.f

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Underner M, Perriot J, Peiffer G, Jaafari N

[Asthma and heroin use].

Presse medicale (Paris, France : 1983). 2017;46(7-8 Pt 1):660-675

Doshi V, Shenoy S, Ganesh A, Lankala S, Henkle J

Near Fatal Asthma in an Inner City Population.

American journal of therapeutics. 2016;23(6):e1375-e1380

Elia D, Marinou A, Chetta A

Life-threatening asthma after heroin inhalation. A case report and a review of the literature.

Acta bio-medica : Atenei Parmensis. 2010;81(1):63-7

Whale CI, Molyneux AW, Ward MJ

Inhaled heroin causing a life-threatening asthma exacerbation and marked peripheral eosinophilia.

British journal of hospital medicine (London, England : 2005). 2007;68(6):332-3

Levine M, Iliescu ME, Margellos-Anast H, Estarziau M, Ansell DA

The effects of cocaine and heroin use on intubation rates and hospital utilization in patients with acute asthma exacerbations.

Chest. 2005;128(4):1951-7

Krantz AJ, Hershow RC, Prachand N, Hayden DM, Franklin C, Hryhorczuk DO

Heroin insufflation as a trigger for patients with life-threatening asthma.

Chest. 2003;123(2):510-7

Cygan J, Trunsky M, Corbridge T

Inhaled heroin-induced status asthmaticus: five cases and a review of the literature.

Chest. 2000;117(1):272-5