The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Gil Braga B, Cravo M, Neves P, Pinto F, Mendonça C

A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors.

Acta medica portuguesa. 2022;35(7-8):588-590

Soo Hoo GW, Lin HK, Junaid I, Klaustermeyer WB

Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.

The American journal of medicine. 2015;128(7):785-9

McFarland KK, Fung EY

Enalapril-induced angioedema: a dental concern.

General dentistry. 2011;59(2):148-50

Bramante RM, Rand M

Images in clinical medicine. Angioedema.

The New England journal of medicine. 2011;365(2):e4

Sánchez-Borges M, González-Aveledo LA

Angiotensin-converting enzyme inhibitors and angioedema.

Allergy, asthma & immunology research. 2010;2(3):195-8

Cupido C, Rayner B

Life-threatening angio-oedema and death associated with the ACE inhibitor enalapril.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2007;97(4):244-5

Kostis JB, Kim HJ, Rusnak J, Casale T, Kaplan A, Corren J, Levy E

Incidence and characteristics of angioedema associated with enalapril.

Archives of internal medicine. 2005;165(14):1637-42

Forslund T, Tohmo H, Weckström G, Stenborg M, Järvinen S

Angio-oedema induced by enalapril.

Journal of internal medicine. 1995;238(2):179-81

Giannoccaro PJ, Wallace GJ, Higginson LA, Williams WL

Fatal angioedema associated with enalapril.

The Canadian journal of cardiology. 1989;5(7):335-6

Huwyler T, Wüthrich B, Mühlethaler K, Kuhn H, Jungbluth H, Späth P, Hochreutener H

[Angioedema caused by enalapril (Reniten)].

Schweizerische medizinische Wochenschrift. 1989;119(37):1253-6