The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

Hieger MA, Afeld JL, Cumpston KL, Wills BK

Topical Benzocaine and Methemoglobinemia.

American journal of therapeutics 2017 Sep/Oct;24;e596-e598 — 2017 Sep/Oct — e596-e598

Brown C, Bowling M

Methemoglobinemia in bronchoscopy: a case series and a review of the literature.

Journal of bronchology & interventional pulmonology 2013 Jul;20;241-6 — 2013 Jul — 241-6

Chowdhary S, Bukoye B, Bhansali AM, Carbo AR, Adra M, Barnett S, Aronson MD, Leffler DA

Risk of topical anesthetic-induced methemoglobinemia: a 10-year retrospective case-control study.

JAMA internal medicine 2013 May 13;173;771-6 — 2013 May 13 — 771-6

Vallurupalli S, Manchanda S

Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures.

Local and regional anesthesia 2011;4;25-8 — 2011 — 25-8

Doko Y, Iranami H, Fujii K, Yamazaki A, Shimogai M, Hatano Y

Severe methemoglobinemia after dental anesthesia: a warning about propitocaine-induced methemoglobinemia in neonates.

Journal of anesthesia 2010 Dec;24;935-7 — 2010 Dec — 935-7

Young B

Intraoperative detection of methemoglobinemia in a patient given benzocaine spray to relieve discomfort from a nasogastric tube: a case report.

AANA journal 2008 Apr;76;99-102 — 2008 Apr — 99-102

Shachor-Meyouhas Y, Galbraith R, Shavit I

Application of topical analgesia in triage: a potential for harm.

The Journal of emergency medicine 2008 Jul;35;39-41 — 2008 Jul — 39-41

Kwok S, Fischer JL, Rogers JD

Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.

Journal of medical case reports 2008 Jan 23;2;16 — 2008 Jan 23 — 16

Paparella S

Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia.

Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 2005 Oct;31;468-9 — 2005 Oct — 468-9

LeClaire AC, Mullett TW, Jahania MS, Flynn JD

Methemoglobinemia secondary to topical benzocaine use in a lung transplant patient.

The Annals of pharmacotherapy 2005 Feb;39;373-6 — 2005 Feb — 373-6

Balicer RD, Kitai E

Methemoglobinemia caused by topical teething preparation: a case report.

TheScientificWorldJournal 2004 Jul 15;4;517-20 — 2004 Jul 15 — 517-20

Byrne MF, Mitchell RM, Gerke H, Goller S, Stiffler HL, Golioto M, Branch MS, Jowell PS, Baillie J

The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia.

Journal of clinical gastroenterology 2004 Mar;38;225-9 — 2004 Mar — 225-9

Sinisterra S, Miravet E, Alfonso I, Soliz A, Papazian O

Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.

The Journal of pediatrics 2002 Aug;141;285-6 — 2002 Aug — 285-6