The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.b

Hematoma of/around central airway wall potentially causing UAO

Publications

Sutter R, Bruder E, Weissenburg M, Balestra GM

Thyroid hemorrhage causing airway obstruction after intravenous thrombolysis for acute ischemic stroke.

Neurocritical care. 2013;19(3):381-4

Bal M, Atar Y, Salturk Z, Ateş AH, Yağcı S, Coşkun Bal G

Lingual Haematoma due to Tenecteplase in a Patient with Acute Myocardial Infarction.

Case reports in otolaryngology. 2013;2013:239796

Vijayan S, Chase A

Images in clinical medicine. Lingual hematoma after thrombolytic therapy.

The New England journal of medicine. 2011;364(7):e13

Yigla M, Sprecher E, Azzam Z, Guralnik L, Kapeliovich M, Krivoy N

Diffuse alveolar hemorrhage following thrombolytic therapy for acute myocardial infarction.

Respiration; international review of thoracic diseases. 2000;67(4):445-8