The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.i

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Can be life-threatening (see under anaphylaxis). Desensitization/induction of tolerance is a possibility

Publications

Randall JM, Bharne AA, Bazhenova LA

Hypersensitivity reactions to carboplatin and cisplatin in non-small cell lung cancer.

Journal of thoracic disease 2013 Apr;5;E53-7 — 2013 Apr — E53-7

Romano A, Torres MJ, Castells M, Sanz ML, Blanca M

Diagnosis and management of drug hypersensitivity reactions.

The Journal of allergy and clinical immunology 2011 Mar;127;S67-73 — 2011 Mar — S67-73