The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.f

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Malmström K, Kaila M, Kajosaari M, Syvänen P, Juntunen-Backman K

Fatal asthma in Finnish children and adolescents 1976-1998: validity of death certificates and a clinical description.

Pediatric pulmonology 2007 Mar;42;210-5 — 2007 Mar — 210-5

Antonicelli L, Tagliabracci A

Asthma death induced by ibuprofen.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 1995 Aug;50;276-8 — 1995 Aug — 276-8