The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Dasgupta K, Nielson S

Coma and Respiratory Failure in a 2-Year-Old Child After Accidental Overdose of Baclofen.

South Dakota medicine : the journal of the South Dakota State Medical Association 2020 Mar;73;106-110 — 2020 Mar — 106-110

Kamal RM, Qurishi R, De Jong CA

Baclofen and ?-hydroxybutyrate (GHB), a dangerous combination.

Journal of addiction medicine 2015 Jan-Feb;9;75-7 — 2015 Jan-Feb — 75-7

Kiel LB, Hoegberg LC, Jansen T, Petersen JA, Dalhoff KP

A nationwide register-based survey of baclofen toxicity.

Basic & clinical pharmacology & toxicology 2015 May;116;452-6 — 2015 May — 452-6

Stroud J, Scattoloni J, Blasingim M, Nafiu OO

Intrathecal baclofen toxicity: an unusual cause of paediatric postoperative coma and respiratory depression.

European journal of anaesthesiology 2014 Jun;31;334-6 — 2014 Jun — 334-6

Choo YM, Kim GB, Choi JY, Park JH, Park JH, Yang CW, Kim YS, Bang BK

Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD.

Nephron 2000 Dec;86;546-7 — 2000 Dec — 546-7