The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Amano H, Kitagawa Y, Hayakawa T, Muto T, Okumura A, Iwayama H

Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2021;17(1):70

Chung JH, Ahn KR, Chun HJ, Kim CS, Kang KS, Yoo SH, Chung JW

Allergic reactions after intravenous injection of methylprednisolone: A case report.

Korean journal of anesthesiology. 2009;57(4):499-502

Porcaro F, Paglietti MG, Diamanti A, Petreschi F, Schiavino A, Negro V, Pecora V, Fiocchi A, Cutrera R

Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy.

Italian journal of pediatrics. 2017;43(1):104

Levy Y, Segal N, Nahum A, Marcus N, Garty BZ

Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.

The journal of allergy and clinical immunology. In practice. 2014;2(4):471-4

Ben Said B, Leray V, Nicolas JF, Rozieres A, Berard F

Methylprednisolone-induced anaphylaxis: diagnosis by skin test and basophil activation test.

Allergy. 2010;65(4):531-2

Nahum A, Garty BZ, Marcus N, Shoenfeld T, Levy Y

Severe hypersensitivity reactions to corticosteroids in children.

Pediatric emergency care. 2009;25(5):339-41

Nakamura H, Matsuse H, Obase Y, Mitsuta K, Tomari S, Saeki S, Kawano T, Kondo Y, Machida I, Shimoda T, Asai S, Kohno S

Clinical evaluation of anaphylactic reactions to intravenous corticosteroids in adult asthmatics.

Respiration; international review of thoracic diseases. 2002;69(4):309-13

Schonwald S

Methylprednisolone anaphylaxis.

The American journal of emergency medicine. 1999;17(6):583-5

Mace S, Vadas P, Pruzanski W

Anaphylactic shock induced by intraarticular injection of methylprednisolone acetate.

The Journal of rheumatology. 1997;24(6):1191-4

McNamara RM

Anaphylaxis after intravenous corticosteroid administration.

The Journal of emergency medicine. 1986;4(3):213-5

Laine-Cessac P, Moshinaly H, Gouello JP, Geslin P, Allain P

[Severe anaphylactoid reactions after intravenous corticosteroids. Report of a case and review of the literature].

Therapie. 1990;45(6):505-8