The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Kehl A, Bergholz M, von Heyden HW, Nagel GA

[Toxic-allergic lung edema following cyclophosphamide and ifosfamide therapy. Case report].

Onkologie 1983 Apr;6;84-6 — 1983 Apr — 84-6

Maxwell I

Letter: Reversible pulmonary edema following cyclophosphamide treatment.

JAMA 1974 Jul 08;229;137-8 — 1974 Jul 08 — 137-8