The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Segura A, Yuste A, Cercos A, López-Tendero P, Gironés R, Pérez-Fidalgo JA, Herranz C

Pulmonary fibrosis induced by cyclophosphamide.

The Annals of pharmacotherapy. 2001;35(7-8):894-7

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine. 1996;154(6 Pt 1):1851-6

Abdel Karim FW, Ayash RE, Allam C, Salem PA

Pulmonary fibrosis after prolonged treatment with low-dose cyclophosphamide. A case report.

Oncology. 1983;40(3):174-6

Burke DA, Stoddart JC, Ward MK, Simpson CG

Fatal pulmonary fibrosis occurring during treatment with cyclophosphamide.

British medical journal (Clinical research ed.). 1982;285(6343):696

Topilow AA, Rothenberg SP, Cottrell TS

Interstitial pneumonia after prolonged treatment with cyclophosphamide.

The American review of respiratory disease. 1973;108(1):114-7

Stentoft J

Progressive pulmonary fibrosis complicating cyclophosphamide therapy.

Acta medica Scandinavica. 1987;221(4):403-7

Tucker AS, Newman AJ, Alvorado C

Pulmonary, pleural and thoracic changes complicating chemotherapy.

Radiology. 1977;125(3):805-9

Richter JE, Hastedt R, Dalton JF, Marshall D, Raymond LW

Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.

Cancer. 1979;43(5):1607-12

Alvarado CS, Boat TF, Newman AJ

Late-onset pulmonary fibrosis and chest deformity in two children treated with cyclophosphamide.

The Journal of pediatrics. 1978;92(3):443-6