The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

Publications

Menon SP, Rajkumar SV, Lacy M, Falco P, Palumbo A

Thromboembolic events with lenalidomide-based therapy for multiple myeloma.

Cancer 2008 Apr 01;112;1522-8 — 2008 Apr 01 — 1522-8

Hirsh J

Risk of thrombosis with lenalidomide and its prevention with aspirin.

Chest 2007 Jan;131;275-7 — 2007 Jan — 275-7

Bennett CL, Angelotta C, Yarnold PR, Evens AM, Zonder JA, Raisch DW, Richardson P

Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer.

JAMA 2006 Dec 06;296;2558-60 — 2006 Dec 06 — 2558-60