The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Hadley A, Slaven JE, Krupp NL, Kloepfer KM

Nonsteroidal anti-inflammatory drug hypersensitivity in a pediatric severe asthmatic population.

Pediatric pulmonology. 2023;58(10):2983-2986

Fu LS, Lin CC, Wei CY, Lin CH, Huang YC

Risk of acute exacerbation between acetaminophen and ibuprofen in children with asthma.

PeerJ. 2019;7:e6760

Su YM, Huang CS, Wan KS

Short-term ibuprofen treatment and pulmonary function in children with asthma.

Indian pediatrics. 2015;52(8):691-3

Kader A, Hildebrandt T, Powell C

How safe is ibuprofen in febrile asthmatic children?

Archives of disease in childhood. 2004;89(9):885-6

Antonicelli L, Tagliabracci A

Asthma death induced by ibuprofen.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 1995;50(4):276-8