The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Soriano FG, Vianna Edos S, Velasco IT

Neuroleptic-induced acute respiratory distress syndrome.

Sao Paulo medical journal = Revista paulista de medicina 2003 May 05;121;121-4 — 2003 May 05 — 121-4

Savici D, Katzenstein AL

Diffuse alveolar damage and recurrent respiratory failure: report of 6 cases.

Human pathology 2001 Dec;32;1398-402 — 2001 Dec — 1398-402

Johnson MD, Newman JH, Baxter JW

Neuroleptic malignant syndrome presenting as adult respiratory distress syndrome and disseminated intravascular coagulation.

Southern medical journal 1988 Apr;81;543-5 — 1988 Apr — 543-5

Varnell RM, Godwin JD, Richardson ML, Vincent JM

Adult respiratory distress syndrome from overdose of tricyclic antidepressants.

Radiology 1989 Mar;170;667-70 — 1989 Mar — 667-70