The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Schjelderup P, El-Galaly TC, Frøkjær JB, Ring T

Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus.

Zeitschrift fur Rheumatologie. 2014;73(10):939-41

Alessandrino EP, Bernasconi P, Colombo A, Caldera D, Martinelli G, Vitulo P, Malcovati L, Nascimbene C, Varettoni M, Volpini E, Klersy C, Bernasconi C

Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.

Bone marrow transplantation. 2000;25(3):309-13

Cuguillière A, Bérard H, N'Guyen G, Miltgen J, Martet G, Eskandari J, Bonnet D

[Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature].

Revue de pneumologie clinique. 1999;55(2):100-4

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine. 1996;154(6 Pt 1):1851-6

Topilow AA, Rothenberg SP, Cottrell TS

Interstitial pneumonia after prolonged treatment with cyclophosphamide.

The American review of respiratory disease. 1973;108(1):114-7