The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
Publications
Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus.
Zeitschrift fur Rheumatologie 2014 Dec;73;939-41 — 2014 Dec — 939-41
Alessandrino EP, Bernasconi P, Colombo A, Caldera D, Martinelli G, Vitulo P, Malcovati L, Nascimbene C, Varettoni M, Volpini E, Klersy C, Bernasconi C
Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.
Bone marrow transplantation 2000 Feb;25;309-13 — 2000 Feb — 309-13
[Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature].
Revue de pneumologie clinique 1999 Apr;55;100-4 — 1999 Apr — 100-4
Lung toxicity associated with cyclophosphamide use. Two distinct patterns.
American journal of respiratory and critical care medicine 1996 Dec;154;1851-6 — 1996 Dec — 1851-6
Interstitial pneumonia after prolonged treatment with cyclophosphamide.
The American review of respiratory disease 1973 Jul;108;114-7 — 1973 Jul — 114-7