The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.m

Chest deformity: platythorax

Publications

Ito T, Koyama S, Iwamoto S, Hirayama M, Azuma E

Acquired Platythorax, or Anteroposterior Flattening of the Chest Wall, as a Late Complication of Cyclophosphamide Treatment for Childhood Acute Lymphoblastic Leukemia, Presenting in a Young Man with Respiratory Failure.

The American journal of case reports 2018 Nov 05;19;1317-1323 — 2018 Nov 05 — 1317-1323

Alvarado CS, Boat TF, Newman AJ

Late-onset pulmonary fibrosis and chest deformity in two children treated with cyclophosphamide.

The Journal of pediatrics 1978 Mar;92;443-6 — 1978 Mar — 443-6