The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Shablak A, Conn A

A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment.

Targeted oncology. 2014;9(2):177-80

Achermann Y, Frauenfelder T, Obrist S, Zaugg K, Corti N, Günthard HF

A rare but severe pulmonary side effect of cetuximab in two patients.

BMJ case reports. 2012;2012