The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.b

Valvular heart disease and/or dysfunction

Publications

Surapaneni P, Vinales KL, Najib MQ, Chaliki HP

Valvular heart disease with the use of fenfluramine-phentermine.

Texas Heart Institute journal. 2011;38(5):581-3

Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL

Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Circulation. 2000;102(23):2836-41

Li R, Serdula MK, Williamson DF, Bowman BA, Graham DJ, Green L

Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1999;23(9):926-8

Thompson PD

Valvular heart disease associated with fenfluramine-phentermine.

The New England journal of medicine. 1997;337(24):1772; author reply 1775

Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV

Valvular heart disease associated with fenfluramine-phentermine.

The New England journal of medicine. 1997;337(9):581-8