The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Suthar KH, Al Mutar S, Venkatesan R

Oxaliplatin-induced Pulmonary Toxicity: A Rare but Serious Complication.

Cureus 2020 Mar 31;12;e7483 — 2020 Mar 31 — e7483

Sánchez Cendra C, Juez Martel I, Gutierrez Abad D

Interstitial lung disease caused by oxaliplatin. An uncommon but not unknown complication.

Archivos de bronconeumologia 2017 Apr;53;213-215 — 2017 Apr — 213-215

Pontes LB, Armentano DP, Soares A, Gansl RC

Fatal pneumonitis induced by oxaliplatin: description of three cases.

Case reports in oncology 2012 Jan;5;104-9 — 2012 Jan — 104-9