The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Hutten EM, van de Ven AAJM, Mencke R, Pleijhuis RG

Angioedema After Use of Recombinant Tissue-Type Plasminogen Activators in Stroke.

Stroke. 2024;55(8):2193-2197

Kim C, Hladik A

Angioedema Secondary to tPA Use in Acute Ischemic Stroke Patient with Hypertension: A Case Report.

Clinical practice and cases in emergency medicine. 2021;5(2):159-162

Mazzoli CA, D Angelo MI, Simonetti L, Cirillo L, Zini A, Gentile M, Gordini G, Coniglio C

Angioedema after rt-PA infusion led to airway emergency: a case report of rescue treatment with fresh frozen plasma.

Brazilian journal of anesthesiology (Elsevier). 2023;73(2):223-226

Diestro JDB, Sedano LSP, Reyes NGD, San Jose MCZ

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2019;28(5):e44-e45

Rathbun KM

Angioedema after thrombolysis with tissue plasminogen activator: an airway emergency.

Oxford medical case reports. 2019;2019(1):omy112

Sczepanski M, Bozyk P

Institutional Incidence of Severe tPA-Induced Angioedema in Ischemic Cerebral Vascular Accidents.

Critical care research and practice. 2018;2018:9360918

Pahs L, Droege C, Kneale H, Pancioli A

A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator Administration.

Annals of emergency medicine. 2016;68(3):345-8

Correia AS, Matias G, Calado S, Lourenço A, Viana-Baptista M

Orolingual angiodema associated with alteplase treatment of acute stroke: a reappraisal.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2015;24(1):31-40

Foster-Goldman A, McCarthy D

Angioedema from recombinant TPA administration: case report and pathophysiology review.

American journal of therapeutics. 2013;20(6):691-3

Yayan J

Lingual angioedema with macroglossia during the treatment of acute ischemic stroke with alteplase.

International journal of general medicine. 2012;5:183-6

Fugate JE, Kalimullah EA, Wijdicks EF

Angioedema after tPA: what neurointensivists should know.

Neurocritical care. 2012;16(3):440-3

Ottomeyer C, Sick C, Hennerici MG, Szabo K

[Orolingual angioedema under systemic thrombolysis with rt-PA: an underestimated side effect].

Der Nervenarzt. 2009;80(4):459-63

Giménez-Muñoz A, Capablo-Liesa JL, Torné-Hernández L, Sagarra-Mur D, Sebastián-Torres B, Alarcia-Alejos R

[Orolingual angioedema secondary to alteplase treatment in cases of stroke].

Revista de neurologia. 2008;46(6):382

Laubinger R, Guthke K, Erdmann U, Klein U

[Angioneurotic orolingual edema associated with the use of rt-PA following a stroke].

Der Anaesthesist. 2007;56(10):1024-7

Molinaro G, Gervais N, Adam A

Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach.

Stroke. 2002;33(6):1712-6

Hill MD, Barber PA, Takahashi J, Demchuk AM, Feasby TE, Buchan AM

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2000;162(9):1281-4