The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Shiota T, Kawanishi H, Inoue S, Egawa J, Kawaguchi M

Risk factors for bradypnea in a historical cohort of surgical patients receiving fentanyl-based intravenous analgesia.

JA clinical reports. 2018;4(1):46

Kuczyńska K, Grzonkowski P, Kacprzak Ł, Zawilska JB

Abuse of fentanyl: An emerging problem to face.

Forensic science international. 2018;289:207-214

Tomassoni AJ, Hawk KF, Jubanyik K, Nogee DP, Durant T, Lynch KL, Patel R, Dinh D, Ulrich A, D'Onofrio G

Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.

MMWR. Morbidity and mortality weekly report. 2017;66(4):107-111

Wu G, Wu G, Wu H

A Costly Lesson: Fatal Respiratory Depression Induced by Clindamycin during Postoperative Patient Controlled Analgesia.

Pain physician. 2015;18(3):E429-31

Matsuki Y, Mizogam M, Tabata M, Matsuki Y, Yasuda Y, Shigemi K

Suspected respiratory depression associated with use of transdermal fentanyl patch.

Pain physician. 2012;15(4):E536-7

D'Orazio JL, Fischel JA

Recurrent respiratory depression associated with fentanyl transdermal patch gel reservoir ingestion.

The Journal of emergency medicine. 2012;42(5):543-8

Topacoglu H, Karcioglu O, Cimrin AH, Arnold J

Respiratory arrest after low-dose fentanyl.

Annals of Saudi medicine. 2005;25(6):508-10

Coon TP, Miller M, Kaylor D, Jones-Spangle K

Rectal insertion of fentanyl patches: a new route of toxicity.

Annals of emergency medicine. 2005;46(5):473

Magosso E, Ursino M, van Oostrom JH

Opioid-induced respiratory depression: a mathematical model for fentanyl.

IEEE transactions on bio-medical engineering. 2004;51(7):1115-28

Tracqui A, Tournoud C, Flesch F, Kopferschmitt J, Kintz P, Deveaux M, Ghysel MH, Marquet P, Pépin G, Petit G, Jaeger A, Ludes B

[Acute poisoning during substitution therapy based on high-dosage buprenorphine. 29 clinical cases--20 fatal cases].

Presse medicale (Paris, France : 1983). 1998;27(12):557-61