The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Shiota T, Kawanishi H, Inoue S, Egawa J, Kawaguchi M

Risk factors for bradypnea in a historical cohort of surgical patients receiving fentanyl-based intravenous analgesia.

JA clinical reports 2018 Jun 13;4;46 — 2018 Jun 13 — 46

Kuczy?ska K, Grzonkowski P, Kacprzak ?, Zawilska JB

Abuse of fentanyl: An emerging problem to face.

Forensic science international 2018 Aug;289;207-214 — 2018 Aug — 207-214

Tomassoni AJ, Hawk KF, Jubanyik K, Nogee DP, Durant T, Lynch KL, Patel R, Dinh D, Ulrich A, D'Onofrio G

Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.

MMWR. Morbidity and mortality weekly report 2017 Feb 03;66;107-111 — 2017 Feb 03 — 107-111

Wu G, Wu G, Wu H

A Costly Lesson: Fatal Respiratory Depression Induced by Clindamycin during Postoperative Patient Controlled Analgesia.

Pain physician 2015 May-Jun;18;E429-31 — 2015 May-Jun — E429-31

Matsuki Y, Mizogam M, Tabata M, Matsuki Y, Yasuda Y, Shigemi K

Suspected respiratory depression associated with use of transdermal fentanyl patch.

Pain physician 2012 Jul-Aug;15;E536-7 — 2012 Jul-Aug — E536-7

D'Orazio JL, Fischel JA

Recurrent respiratory depression associated with fentanyl transdermal patch gel reservoir ingestion.

The Journal of emergency medicine 2012 May;42;543-8 — 2012 May — 543-8

Topacoglu H, Karcioglu O, Cimrin AH, Arnold J

Respiratory arrest after low-dose fentanyl.

Annals of Saudi medicine 2005 Nov-Dec;25;508-10 — 2005 Nov-Dec — 508-10

Coon TP, Miller M, Kaylor D, Jones-Spangle K

Rectal insertion of fentanyl patches: a new route of toxicity.

Annals of emergency medicine 2005 Nov;46;473 — 2005 Nov — 473

Magosso E, Ursino M, van Oostrom JH

Opioid-induced respiratory depression: a mathematical model for fentanyl.

IEEE transactions on bio-medical engineering 2004 Jul;51;1115-28 — 2004 Jul — 1115-28

Tracqui A, Tournoud C, Flesch F, Kopferschmitt J, Kintz P, Deveaux M, Ghysel MH, Marquet P, Pépin G, Petit G, Jaeger A, Ludes B

[Acute poisoning during substitution therapy based on high-dosage buprenorphine. 29 clinical cases--20 fatal cases].

Presse medicale (Paris, France : 1983) 1998 Mar 28;27;557-61 — 1998 Mar 28 — 557-61