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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Zambratto J, Gottesman E, Hasan Z, Heuser W, Kuschner CE, Mundanchira G, Spaeth KR, Nogar J

Extracorporeal Membrane Oxygenation in the Treatment of Acute Elemental Mercury Inhalation Toxicity.

Chest. 2025;167(3):e71-e74

Peregrina-Chávez AG, Ramírez-Galindo MDR, Chávez-Martínez R, Delahanty-Delgado CA, Vazquez-Alaniz F

Full Atrioventricular Block Secondary to Acute Poisoning Mercury: A Case Report.

International journal of environmental research and public health. 2018;15(4)

De Palma G, Mariotti O, Lonati D, Goldoni M, Catalani S, Mutti A, Locatelli C, Apostoli P

Toxicokinetics and toxicodynamics of elemental mercury following self-administration.

Clinical toxicology (Philadelphia, Pa.). 2008;46(9):869-76

Clarkson TW, Magos L, Myers GJ

The toxicology of mercury--current exposures and clinical manifestations.

The New England journal of medicine. 2003;349(18):1731-7

Lim HE, Shim JJ, Lee SY, Lee SH, Kang SY, Jo JY, In KH, Kim HG, Yoo SH, Kang KH

Mercury inhalation poisoning and acute lung injury.

The Korean journal of internal medicine. 1998;13(2):127-30

Moromisato DY, Anas NG, Goodman G

Mercury inhalation poisoning and acute lung injury in a child. Use of high-frequency oscillatory ventilation.

Chest. 1994;105(2):613-5

Jaffe KM, Shurtleff DB, Robertson WO

Survival after acute mercury vapor poisoning.

American journal of diseases of children (1960). 1983;137(8):749-51