The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
Publications
Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus.
Zeitschrift fur Rheumatologie 2014 Dec;73;939-41 — 2014 Dec — 939-41
Cyclophosphamide-induced acute respiratory distress syndrome.
Respirology (Carlton, Vic.) 2007 Sep;12;769-73 — 2007 Sep — 769-73
Moghrabi A, Fuchs H, Brown M, Schold SC, Graham M, Kurtzberg J, Tien R, Felsberg G, Lachance DH, Colvin OM
Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma.
Medical and pediatric oncology 1995 Sep;25;190-6 — 1995 Sep — 190-6
Interstitial pneumonia after prolonged treatment with cyclophosphamide.
The American review of respiratory disease 1973 Jul;108;114-7 — 1973 Jul — 114-7