The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
ARDS due to alcohol is thought to occur primarily following aspiration (PMID 24811480)
Publications
The Effect of Alcohol Consumption on the Risk of ARDS: A Systematic Review and Meta-Analysis.
Chest. 2018;154(1):58-68
Lee A, Festic E, Park PK, Raghavendran K, Dabbagh O, Adesanya A, Gajic O, Bartz RR, United States Critical Illness and Injury Trials Group
Characteristics and outcomes of patients hospitalized following pulmonary aspiration.
Chest. 2014;146(4):899-907
Epidemiology of acute lung injury and acute respiratory distress syndrome in The Netherlands: a survey.
Respiratory medicine. 2007;101(10):2091-8
Alcohol abuse and acute lung injury: epidemiology and pathophysiology of a recently recognized association.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2005;53(5):235-45