The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.n

ILD with a granulomatous component

Publications

Saito Y, Kunugi S, Suzuki Y, Narita K, Miura Y, Minegishi Y, Kimura G, Kondo Y, Azuma A, Fukuda Y, Gemma A

Granuloma-forming interstitial pneumonia occurring one year after the start of everolimus therapy.

Internal medicine (Tokyo, Japan) 2013;52;263-7 — 2013 — 263-7

Mizuno R, Asano K, Mikami S, Nagata H, Kaneko G, Oya M

Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma.

Japanese journal of clinical oncology 2012 May;42;442-6 — 2012 May — 442-6