The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Thiis pattern can be diifficult to separate from mild or early DAD Howerver, the BAL shows elevated lymphocyte counts, vs. neutrophils in DAD

Publications

Pugh D, Farrah TE, Gallacher PJ, Kluth DC, Dhaun N

Cyclophosphamide-Induced Lung Injury.

Kidney international reports. 2019;4(3):484-486

Cuguillière A, Bérard H, N'Guyen G, Miltgen J, Martet G, Eskandari J, Bonnet D

[Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature].

Revue de pneumologie clinique. 1999;55(2):100-4

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine. 1996;154(6 Pt 1):1851-6

Usui Y, Aida H, Kimula Y, Miura H, Aoyagi Y, Nakayama M, Takayama S

A case of cyclophosphamide-induced interstitial pneumonitis diagnosed by bronchoalveolar lavage.

Respiration; international review of thoracic diseases. 1992;59(2):125-8