Pneumotox » Pattern » X.b - Antiphospholipid antibodies w/wo the APL syndrome

X.b

Antiphospholipid antibodies w/wo the APL syndrome

Antiphospholipid- or antisynthetase Ab syndrome (APS-APLS). Including circulating lupus anticoagulant, anticardiolipin Ab and anti-beta2glycoprotein Ab. Possible complications include VTE, pulmonary thromboembolism, pulmonary hypertension, DAH and ILD

Last update : 01/01/1970

Causative drugs

26

Valsartan

VIII.a X.b

1

1
2

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

X.b

Antiphospholipid antibodies w/wo the APL syndrome

Causative drugs

Valsartan