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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XV.bd
Path: Bronchiolar necrosis & vasculitis
Last update :
01/01/1970
Causative drugs
1
Sauropus androgynus
IV.c
IV - Airway involvement
IV.c - Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)
IV.k
IV - Airway involvement
IV.k - Bronchiectasis
IV.n
IV - Airway involvement
IV.n - Obstructive airway dysfunction (see also IVc, XVx)
XII.t
XII - Cardiovascular involvement / toxicity
XII.t - Torsades de pointe
XV.z
XV - Pathology
XV.z - Path: Obliterative (constrictive) bronchiolitis (see also IVc, IVn)
XV.bb
XV - Pathology
XV.bb - Path: Airway inflammation
XV.bd
XV - Pathology
XV.bd - Path: Bronchiolar necrosis & vasculitis
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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