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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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VI.q

Rebound pulmonary arterial hypertension

Upon sudden vasodilator drug discontinuation or withdrawal

Last update : 01/01/1970
 

Causative drugs

2

Nitric oxide (NO)

II.a II - Pulmonary edema - Acute lung injury - ARDS
II.a - Pulmonary edema, noncardiogenic (NCPE)
II.f II - Pulmonary edema - Acute lung injury - ARDS
II.f - Hypoxemia, low oxygen saturation (may occur in isolation)
VI.q VI - Pulmonary vasculopathies
VI.q - Rebound pulmonary arterial hypertension
XIV.a XIV - Hemoglobinopathies - Abnormal hemoglobin states (acquired)
XIV.a - Methemoglobinemia
1

Prostacyclin

I.b I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
II.a II - Pulmonary edema - Acute lung injury - ARDS
II.a - Pulmonary edema, noncardiogenic (NCPE)
II.d II - Pulmonary edema - Acute lung injury - ARDS
II.d - Pulmonary edema, cardiogenic
VI.i VI - Pulmonary vasculopathies
VI.i - Acute pulmonary hypertension
VI.q VI - Pulmonary vasculopathies
VI.q - Rebound pulmonary arterial hypertension
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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