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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitric oxide (NO)

4

XIV.a Methemoglobinemia

2
Last update : 12/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial.
American journal of respiratory and critical care medicine 2023 Dec 15;208;1293-1304 2023 Dec 15
Methemoglobinemia due to nitric oxide therapy in a child after cardiac surgery.
Asian cardiovascular & thoracic annals 2013 Jun;21;345-7 2013 Jun
'Safe' methaemoglobin concentrations are a mortality risk factor in patients receiving inhaled nitric oxide.
Anaesthesia and intensive care 2011 Sep;39;919-25 2011 Sep
Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.
The Journal of pediatrics 2002 Aug;141;285-6 2002 Aug
Inhaled nitric oxide and methemoglobin in full-term infants with persistent pulmonary hypertension of the newborn.
Pulmonary pharmacology & therapeutics 2002;15;1-5 2002
The toxicology of inhaled nitric oxide.
Toxicological sciences : an official journal of the Society of Toxicology 2001 Jan;59;5-16 2001 Jan
Methaemoglobinaemia after inhalation of nitric oxide for treatment of hydrochlorothiazide-induced pulmonary oedema.
Lancet (London, England) 1996 Oct 12;348;1035-6 1996 Oct 12

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