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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Prostacyclin

3

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 09/07/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Epoprostenol
3
Prostaglandins
1

Publications

Pulmonary Edema Following Initiation of Parenteral Prostacyclin Therapy for Pulmonary Arterial Hypertension: A Retrospective Study.
Chest 2019 Jul;156;45-52 2019 Jul
Safety and efficacy of epoprostenol therapy in pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.
Circulation journal : official journal of the Japanese Circulation Society 2012;76;1729-36 2012
Acute pulmonary edema caused by epoprostenol infusion in a child with scimitar syndrome and pulmonary hypertension.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003 Jan;4;111-4 2003 Jan
Pulmonary edema complicating prostacyclin therapy in pulmonary hypertension associated with scleroderma: a case of pulmonary capillary hemangiomatosis.
Arthritis and rheumatism 2000 Mar;43;699-703 2000 Mar
Pulmonary edema during acute infusion of epoprostenol in a patient with pulmonary hypertension and limited scleroderma.
The Journal of rheumatology 1999 May;26;1195-6 1999 May
Pulmonary edema complicating continuous intravenous prostacyclin in pulmonary capillary hemangiomatosis.
American journal of respiratory and critical care medicine 1998 May;157;1681-5 1998 May
Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.
Chest 1998 Jan;113;237-40 1998 Jan

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