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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients-Vehicle-Preservatives (of drugs)

5

XV.q Path: Foreign body deposits/granulomatous reaction

1
Last update : 13/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Benzylbenzoate
1
Cremophor
1
Crospovidone
2
Preservatives
2
Ricin (Castor oil)
2
Sesame oil
1
Soybean
1
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.
The American journal of forensic medicine and pathology 2022 Mar 01;43;81-89 2022 Mar 01
Rapid development of pulmonary hypertension and right ventricular failure due to large vessel intravascular microcrystalline cellulosis in an intravenous drug user.
Pulmonary circulation 2020;10;2045894020907871 2020
Pulmonary hypertension and foreign body granulomas in intravenous drug abusers. Documentation by cardiac catheterization and lung biopsy.
The American journal of medicine 1976 Nov;61;657-64 1976 Nov

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