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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients-Vehicle-Preservatives (of drugs)

5

IV.a Bronchospasm - Wheezing - Asthma

2
Last update : 04/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Benzylbenzoate
1
Cremophor
1
Crospovidone
2
Preservatives
2
Ricin (Castor oil)
2
Sesame oil
1
Soybean
1
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Paradoxical bronchospasm from benzalkonium chloride (BAC) preservative in albuterol nebulizer solution in a patient with acute severe asthma. A case report and literature review of airway effects of BAC.
Respiratory medicine case reports 2017;21;39-41 2017
Hypersensitivity reaction after inhalation of a lactose-containing dry powder inhaler.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 2014 Jul;19;206-11 2014 Jul
Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution.
British medical journal (Clinical research ed.) 1987 May 09;294;1197-8 1987 May 09

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