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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Excipients-Vehicle-Preservatives (of drugs)
5
IV.f
Severe or catastrophic bronchospasm or asthma attack (can be fatal)
1
Last update :
29/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Amiodarone
Benzylbenzoate
Cremophor
Crospovidone
Preservatives
Ricin (Castor oil)
Sesame oil
Soybean
Talc (inhaled, sniffed, i.v., intrapleural)
Publications
[Severe bronchospasm using Diprivan® in a patient allergic to peanut and birch].