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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients-Vehicle-Preservatives (of drugs)

5

VI.g Foreign body pulmonary vasculopathy (Excipient lung disease)

3
Last update : 05/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Benzylbenzoate
1
Cremophor
1
Crospovidone
2
Preservatives
2
Ricin (Castor oil)
2
Sesame oil
1
Soybean
1
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Intravenous injection of pharmaceutical tablets presenting as multiple pulmonary nodules and declining pulmonary function in an adolescent with cystic fibrosis.
Pediatrics 2006 Sep;118;e924-8 2006 Sep
Embolized crospovidone (poly[N-vinyl-2-pyrrolidone]) in the lungs of intravenous drug users.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003 Apr;16;286-92 2003 Apr
Pulmonary granulomatous vasculitis induced by insoluble particulates: a case report.
Ultrastructural pathology 2003;27;439-49 2003
Images in clinical medicine. Pulmonary granulomas in an intravenous drug user.
The New England journal of medicine 2000 Nov 02;343;1312 2000 Nov 02

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