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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Warfarin

5

VIII.q Tongue involvement (edema, glossitis, hematoma)

2
Last update : 07/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cocaine
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4

Publications

Upper Airway Hematoma Secondary to Warfarin Therapy: A Systematic Review of Reported Cases.
North American journal of medical sciences 2015 Nov;7;494-502 2015 Nov
Warfarin induced sublingual hematoma: a Ludwig angina mimic.
American journal of otolaryngology 2015;36;84-6 2015
Spontaneous lingual and sublingual haematoma: a rare complication of warfarin use.
BMJ case reports 2014 Jul 09;2014; 2014 Jul 09
Spontaneous sublingual haematoma in a patient treated with warfarin.
Acta anaesthesiologica Scandinavica 2013 Apr;57;530-1 2013 Apr
Lingual and sublingual hematoma causing upper airway obstruction.
The Journal of emergency medicine 2012 Dec;43;1075-6 2012 Dec
Lingual haematoma: a rare complication of usual warfarin dose.
Emergency medicine journal : EMJ 2008 Jul;25;406 2008 Jul
Lingual hematoma threatening airway obstruction in a patient on oral anticoagulation with warfarin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007 Sep;18;575-6 2007 Sep

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