The main signs and symptoms include fever, dyspnea, chest pain, and cough. Imaging features include multiple bilateral peripheral nodules, cavitation, focal or wedge-shaped infiltrates and pleural effusion. Echocardiography may reveal vegetations. Blood cultures can grow Staphylococcus aureus or Candida (PMID 24183289)
v2.2
The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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