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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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  • Drugs
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Abused drugs/substances (illicit-, street drugs - IV/inhaled)

5

VI.g Foreign body pulmonary vasculopathy (Excipient lung disease)

2
Last update : 13/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amphetamine (and -derivatives)
3
Amyl-nitrite, butyl-nitrite, isobutyl-nitrite ('Poppers')
4
Antidotes
1
Body packing
4
Cannabinoids - Cannabinoid receptor agonists (synthetic) (K2, Spice)
5
Cathinones, synthetic ('Bath salts')
5
Cocaine
5
Crack cocaine
5
E-cigarette - E-vaporizers - ENDS - Vaping - Dabbing
5
E-cigarette's, e-vaporizer's secondhand vapor (Passive vaping)
1
Excipients-Vehicle-Preservatives (of drugs)
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Inhalants (volatile substances)
5
Marijuana, cannabis (haschish, hash, bang, dab)
5
Methadone
5
Opiates - Opioids - Opium
5
Recreational drugs
5
Sniffed drugs (opioids, acetaminophen)
5
Talc (inhaled, sniffed, i.v., intrapleural)
3
Warfarin
5

Publications

Nonthrombotic pulmonary embolism: a radiological perspective.
Seminars in ultrasound, CT, and MR 2012 Dec;33;522-34 2012 Dec
Intravascular Talcosis due to Intravenous Drug Use Is an Underrecognized Cause of Pulmonary Hypertension.
Pulmonary medicine 2012;2012;617531 2012
The histopathology of drugs of abuse.
Histopathology 2011 Oct;59;579-93 2011 Oct
Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations.
The American journal of forensic medicine and pathology 2005 Jun;26;106-16 2005 Jun
Images in clinical medicine. Pulmonary granulomas in an intravenous drug user.
The New England journal of medicine 2000 Nov 02;343;1312 2000 Nov 02
[Intravenous abuse of crushed tablets. A case with fatal outcome].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 1990 Jun 20;110;2080-1 1990 Jun 20
The effect of oral hydralazine on the pulmonary hemodynamics of patients with pulmonary foreign body granulomatosis.
Chest 1982 Dec;82;708-12 1982 Dec
Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. A complication of pentazocine tablet abuse.
Virchows Archiv. A, Pathological anatomy and histology 1982;395;207-16 1982
Self-induced pulmonary granulomatosis. A consequence of intravenous injection of drugs intended for oral use.
Chest 1980 Jul;78;90-4 1980 Jul
Talc granulomatosis and angiothrombotic pulmonary hypertension in drug addicts.
Journal of the Canadian Association of Radiologists 1974 Jun;25;87-93 1974 Jun
Pulmonary angiothrombotic granulomatosis in drug offenders.
JAMA 1972 Aug 21;221;909-11 1972 Aug 21
Cor pulmonale secondary to talc granulomata in the lungs of a drug addict.
Canadian Medical Association journal 1970 Dec 05;103;1297-8 1970 Dec 05
ANGIOTHROMBOTIC PULMONARY HYPERTENSION IN ADDICTS. "BLUE VELVET" ADDICTION.
JAMA 1964 May 25;188;755-7 1964 May 25

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