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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cocaine

5

VIII.i Midline destructive lesions

3
Last update : 08/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Crack cocaine
5
Levamisole
4
Levamisole-adulterated/tainted cocaine
5
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Invasive aspergillosis in a user of inhaled cocaine: rhinosinusitis with bone and cartilage destruction.
Revista da Sociedade Brasileira de Medicina Tropical 2014 Jul;47;533-6 2014 Jul
The manifestation of cocaine-induced midline destructive lesion in bone tissue and its identification in human skeletal remains.
Forensic science international 2013 Sep 10;231;408.e1-11 2013 Sep 10
Vasculitis mimics: cocaine-induced midline destructive lesions.
The American journal of the medical sciences 2013 Nov;346;430-1 2013 Nov
Cocaine-induced midline destructive lesions - an autoimmune disease?
Autoimmunity reviews 2013 Feb;12;496-500 2013 Feb
Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine.
Clinical and experimental dermatology 2013 Dec;38;878-82 2013 Dec
Sinonasal involvement in systemic vasculitides and cocaine-induced midline destructive lesions: Diagnostic controversies.
Allergy & rhinology (Providence, R.I.) 2013;4;e94-9 2013
Palatal fistula resulting from cocaine abuse: a case report.
European review for medical and pharmacological sciences 2012 Feb;16;280-2 2012 Feb
[Massive destructive sinusitis following cocaine inhalation].
Medicina clinica 2012 Apr 14;138;414 2012 Apr 14
Cocaine-induced midline destruction lesions with positive ANCA test mimicking Wegener's granulomatosis.
Revista brasileira de reumatologia 2012;52;431-7 2012
The growing complexity of the pathology associated with cocaine use.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2011 Jun;17;167-8 2011 Jun
Diagnostic considerations and prosthetic rehabilitation of a cocaine-induced midline destructive lesion: A clinical report.
The Journal of prosthetic dentistry 2010 Jan;103;1-5 2010 Jan
[Palatal necrosis due to cocaine abuse].
Revue de stomatologie et de chirurgie maxillo-faciale 2010 Feb;111;32-5 2010 Feb
A case of cocaine-induced panhypopituitarism with human neutrophil elastase-specific anti-neutrophil cytoplasmic antibodies.
European journal of endocrinology 2009 Mar;160;499-502 2009 Mar
[Wegener granulomatosis and cocaine-induced midline destructive lesion: differential diagnosis].
Medicina clinica 2009 Jul 11;133;237-8 2009 Jul 11
A peculiar case of midface reconstruction with four free flaps in a cocaine-addicted patient.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2009 Feb;62;e33-40 2009 Feb
Cocaine-induced midline destructive lesions mimicking ENT-limited Wegener's granulomatosis.
Scandinavian journal of rheumatology 2008;37;477-80 2008
Midline palate perforation secondary to cocaine abuse.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2008;61;588-90 2008
Cocaine-related syndrome and palatal reconstruction: report of a series of cases.
International journal of oral and maxillofacial surgery 2007 Aug;36;721-7 2007 Aug
Sino-nasal bony and cartilaginous destruction associated with cocaine abuse, S. aureus and antineutrophil cytoplasmic antibodies.
The Netherlands journal of medicine 2006;64;248-51 2006
c-ANCA as a serological pitfall.
Lancet (London, England) 2004 Mar 06;363;782 2004 Mar 06
Sinonasal osteocartilaginous necrosis in cocaine abusers: experience in 25 patients.
American journal of rhinology 2003;17;33-43 2003
Aggressive destructive midfacial lesion from cocaine abuse.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2002 Oct;94;465-70 2002 Oct
Midfacial osteomyelitis in a chronic cocaine abuser: a case report.
Ear, nose, & throat journal 2001 Oct;80;738-40, 742-3 2001 Oct
Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic, and serologic features and their differentiation from Wegener granulomatosis.
Medicine 2001 Nov;80;391-404 2001 Nov
Nasal cocaine abuse mimicking midline granuloma.
Journal of the American Academy of Dermatology 1995 Feb;32;286-7 1995 Feb
Nasal cocaine abuse causing an aggressive midline intranasal and pharyngeal destructive process mimicking midline reticulosis and limited Wegener's granulomatosis.
The Journal of rheumatology 1990 Jun;17;838-40 1990 Jun

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