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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Cocaine
5
III.b
Pneumorenal syndrome (w/wo ANCAs)
2
Last update :
11/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
Crack cocaine
Levamisole
Levamisole-adulterated/tainted cocaine
Talc (inhaled, sniffed, i.v., intrapleural)
Publications
Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease.
Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 cases.