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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paraffin-Vaseline-Oil-Lipids (Mineral or other) p.o./inhaled/aspirated

5

XVII.h Nontuberculous pulmonary mycobacterial infection/superinfection

2
Last update : 01/11/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Camphor
1
Excipients-Vehicle-Preservatives (of drugs)
5
Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated
5
Oil - Paraffin - Lipids (i.v.)
5
Oil-/lipid-based formulations (parenteral)
3
Olive oil
1
Ricin (Castor oil)
2
Sesame oil
1
Shark oil
2
Soybean
1
Vaseline
1
Vicks Vaporub TM (R)
2

Publications

Aggressive mycobacterium abscessus on repeated exogenous lipoid pneumonia in the right middle lobe.
Annals of translational medicine 2019 May;7;206 2019 May
Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants.
Respirology case reports 2018 Oct;6;e00356 2018 Oct
Exogenous lipoid pneumonia superinfected with acid-fast bacilli in infants: a report of nine cases.
Fetal and pediatric pathology 2006;25;107-17 2006
Pathologic quiz case. Chronic pneumonia after gastrectomy. Pathologic diagnosis: chronic aspiration lipoid pneumonia with Mycobacterium abscessus.
Archives of pathology & laboratory medicine 2001 Jul;125;976-8 2001 Jul
Rapidly growing mycobacterial lung infection in association with esophageal disorders.
Mayo Clinic proceedings 1999 Jan;74;45-51 1999 Jan

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