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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Camphor
1
Last update :
21/12/2014
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.d
Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
1
IX.i
Respiratory arrest - Apnea
1
X - Systemic/Distant conditions, syndromes and reactions
X.u
Multiple organ dysfunction/failure (MODS/MOF)
1
XII - Cardiovascular involvement / toxicity
XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
1
XII.m
Cardiac- cardiorespiratory/pulmonary arrest
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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