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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paraffin-Vaseline-Oil-Lipids (Mineral or other) p.o./inhaled/aspirated

5

XIX.h BAL: Exogenous (oil red O-stainable) lipids in BAL macrophages

3
Last update : 27/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Camphor
1
Excipients-Vehicle-Preservatives (of drugs)
5
Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated
5
Oil - Paraffin - Lipids (i.v.)
5
Oil-/lipid-based formulations (parenteral)
3
Olive oil
1
Ricin (Castor oil)
2
Sesame oil
1
Shark oil
2
Soybean
1
Vaseline
1
Vicks Vaporub TM (R)
2

Publications

Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants.
Respirology case reports 2018 Oct;6;e00356 2018 Oct
[Lipoid pneumonia - an underestimated syndrome].
Deutsche medizinische Wochenschrift (1946) 2010 Jan;135;27-31 2010 Jan
Lipoid pneumonia: an overview.
Expert review of respiratory medicine 2010 Dec;4;799-807 2010 Dec
Lipoid pneumonia presenting as non resolving community acquired pneumonia: a case report.
Cases journal 2009 Dec 16;2;9332 2009 Dec 16
Lung infiltrate in a male with a bronchopleural fistula.
The European respiratory journal 2003 Jun;21;1078-80 2003 Jun
Images in clinical medicine. Exogenous lipoid pneumonia.
The New England journal of medicine 1998 Feb 19;338;512 1998 Feb 19
Bronchoalveolar lavage in liquid paraffin pneumonitis.
Chest 1990 Nov;98;1149-55 1990 Nov

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