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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paraffin-Vaseline-Oil-Lipids (Mineral or other) p.o./inhaled/aspirated

5

I.k Lung nodule or nodules

3

Can be tracer-avid on PET-scan

Last update : 18/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Camphor
1
Excipients-Vehicle-Preservatives (of drugs)
5
Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated
5
Oil - Paraffin - Lipids (i.v.)
5
Oil-/lipid-based formulations (parenteral)
3
Olive oil
1
Ricin (Castor oil)
2
Sesame oil
1
Shark oil
2
Soybean
1
Vaseline
1
Vicks Vaporub TM (R)
2

Publications

The reversed halo sign: update and differential diagnosis.
The British journal of radiology 2012 Sep;85;1226-35 2012 Sep
A solitary pulmonary nodule mimicking lung cancer.
American journal of respiratory and critical care medicine 2012 Aug 01;186;e4 2012 Aug 01
[Lipoid pneumonia - an underestimated syndrome].
Deutsche medizinische Wochenschrift (1946) 2010 Jan;135;27-31 2010 Jan
False-positive FDG-PET scan secondary to lipoid pneumonia mimicking a solid pulmonary nodule.
Annals of nuclear medicine 2007 Sep;21;411-4 2007 Sep
An 85-year-old man with a lung mass.
Chest 2004 Mar;125;1121-3 2004 Mar
False-positive PET scan in a patient with lipoid pneumonia simulating lung cancer.
Clinical nuclear medicine 2004 Jul;29;426-8 2004 Jul
A 77-year-old man with a lung mass.
Chest 1997 May;111;1439-41 1997 May
Exogenous lipoid pneumonitis due to Vicks Vaporub inhalation diagnosed by fine needle aspiration cytology.
Cytopathology : official journal of the British Society for Clinical Cytology 1991;2;315-6 1991

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