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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Anticoagulants, oral (vitamin K antagonists-VKA)
5
VII.g
Hemomediastinum - Mediastinal hematoma
1
Last update :
18/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Acenocoumarol
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
Brodifacoum
Coumadin
Dicoumarol
Heparin
Heparin, low-m.w.
Phenprocoumon
Superwarfarins (vitamin K super antagonist rodenticides)
Thrombolytic (fibrinolytic) agents
Warfarin
Publications
[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].
Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.
[Mediastinal bleeding during anticoagulant simulating dissecting hematoma].
Radiologic seminar CXXI: hemomediastinum associated with anticoagulant therapy.
[Unusual radiologic aspect of a mediastinal hematoma].