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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

VII.g Hemomediastinum - Mediastinal hematoma

1
Last update : 18/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].
Giornale italiano di cardiologia 1990 Oct;20;972-5 1990 Oct
Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.
Postgraduate medical journal 1983 Feb;59;95-7 1983 Feb
[Mediastinal bleeding during anticoagulant simulating dissecting hematoma].
Harefuah 1978 Mar;94;172-3 1978 Mar
Radiologic seminar CXXI: hemomediastinum associated with anticoagulant therapy.
Journal of the Mississippi State Medical Association 1972 Oct;13;434-5 1972 Oct
[Unusual radiologic aspect of a mediastinal hematoma].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 1968 Nov 08;44;2827-30 1968 Nov 08

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