Pneumotox » Drug » Thrombolytic (fibrinolytic) agents

Thrombolytic (fibrinolytic) agents

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See under specific drugs/agents including r-tPA

Last update : 11/02/2014

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2

III.c Hemoptysis

1

III.e Pulmonary hematoma

1

V.e Hemothorax - Serosanguineous pleural effusion

1

V.n Hemopericardium - Bloody pericardial effusion

1

VII.g Hemomediastinum - Mediastinal hematoma

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

1

VIII.b Hematoma of/around central airway wall potentially causing UAO

1

XI.k Esophageal hematoma (may cause chest pain and/or tracheal compression)

1

XII.k Constrictive pericarditis - Pericardial thickening

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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