Pneumotox » Drug » Methylene chloride

Methylene chloride

A paint remover with the formula: CH2Cl2. During biotransformation of CH2Cl2, the toxic compounds CO and phosgene are formed

Last update : 13/10/2014

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment