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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methylene chloride

2

XIV.c Carboxyhemoglobinemia

2
Last update : 04/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary toxicity following exposure to methylene chloride and its combustion product, phosgene.
Chest 1992 Mar;101;860-1 1992 Mar
Treatment of methylene chloride induced carbon monoxide poisoning with hyperbaric oxygenation.
Military medicine 1990 Nov;155;570-2 1990 Nov
Hyperbaric oxygen for methylene chloride poisoning: report on two cases.
Annals of emergency medicine 1989 Jun;18;691-5 1989 Jun
Diffuse pulmonary injury following paint remover exposure.
The American journal of medicine 1986 Oct;81;702-4 1986 Oct
Carbon monoxide poisoning secondary to inhaling methylene chloride.
British medical journal 1980 Nov 29;281;1461 1980 Nov 29
Chronic carbon monoxide poisoning caused by methylene chloride paintstripper.
Medicine, science, and the law 1978 Oct;18;238 1978 Oct
Elevated carbon monoxide levels from exposure to methylene chloride.
JAMA 1978 Jun 02;239;2341 1978 Jun 02

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