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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Ethylene-vinyl alcohol copolymer (e.g. Onyx (R))
1
Last update :
18/02/2017
II - Pulmonary edema - Acute lung injury - ARDS
II.a
Pulmonary edema, noncardiogenic (NCPE)
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II.b
ARDS - Acute lung injury
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II.f
Hypoxemia, low oxygen saturation (may occur in isolation)
1
VI - Pulmonary vasculopathies
VI.v
Foreign body/substance pulmonary embolism
1
XI - Miscellaneous
XI.l
Superior vena cava syndrome
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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