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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Antituberculous chemotherapy
2
Last update :
01/12/2018
I - Interstitial/parenchymal lung disease
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
1
I.e
Acute eosinophilic pneumonia (AEP)
1
X - Systemic/Distant conditions, syndromes and reactions
X.a
DRES syndrome - DRESS-like reaction
1
X.i
The immune reconstitution syndrome (IRCS)
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ethambutol
Isoniazid - INH
Para-aminosalicylic acid (PAS)
Rifampicin
