Pneumotox » Drug » Isoniazid - INH

Isoniazid - INH

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Last update : 24/02/2015

I.b Pneumonitis (ILD)

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I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

I.g Pulmonary fibrosis

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IV.a Bronchospasm - Wheezing - Asthma

1

V.b Eosinophilic pleural effusion

1

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

2

V.m Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

1

X.d Lupus - Lupus syndrome (see also Vd)

2

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1

XII.c Pericardial effusion (w/wo tamponade)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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